(Citalopram)-Celexa Our price: $0.74

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International name: to Citalopram Chemical name: y-(e-dimetilaminopropil)-y- (ya-ftorfenil)-y,e-digidroizobenzofuran-shch-karbonitril Medicinal form: the tablets, covered with the tape shell Composition: active material - generic Celexa hydrobromide; the auxiliary substances: starch is maize, lactose monohydrate, kopovidon, glycerin 85%, microcrystalline cellulose, sodium of kroskarmeloza, magnesium stearate. Shell - gipromelloza 5, macro-goal 400, the dioxide of titanium (E 171). Description: 20 mg - oval, pinck colors of tablet, covered with tape shell, with the mark, markirovannye "F" and "P" it is symmetrical near the mark; 40 mg - oval. Pharmacotherapeutic group: antidepressant. Code ATKH: N0ГB04. Pharmacological properties TSIPRAMIL is antidepressant, selective inhibitor of the reverse seizure of serotonin (SIOZS). Pharmacodynamics. Generic celexa it does not have or has very weak ability to be connected with a whole series of receptors, including histaminic, muskarinovye and adrenoreceptors. Buy this to a considerable degree is explained absence in Celexa of kardiotoksichnosti and side-line action in the form of orthostatic hypotonia, sedative effect, dryness in the mouth. Citalopram to the very small degree only inhibits cytochrome R.YASHCH0IID', and therefore it does not interact with the medicines, which are metabolized by this ferment. Antidepressive effect usually is developed after 2-4 weeks of treatment. Celexa does not have an effect on the conducting system of heart and the arterial pressure, to the hematologic indices, the function of the liver and kidneys, is not caused an increase in the mass of body. Pharmacokinetics. Biodostupnost' of Celexa with the internal administration is of about 80%. Maximum concentration in the plasma is reached 2-4 hours after method. Binding with the proteins - is lower than 80%. Metabolism is achieved by demethylation, deamination and oxidation. That not changed to Celexa is basic connection in the plasma of the blood; its kinetics is linear. A constant concentration in the plasma is established in 1-2 weeks of treatment. The period of the half-life of preparation is 1,5 days. Removal is achieved with the urine and the feces. Indications to the application Therapy of the depressions of different etiology and structure in adult. Treatment of the panicky disorder of s/bez of agoraphobia. Treatment Of obsessive-compulsory Disorder (OKR). Contra-evidence generic Celexa is contrasted with the increased sensitivity to tsitalopramu or any of the auxiliary substances. Preparation should not be used in combination with the inhibitors of monoamino oxydase (MAO), including selegilinom, or during 14 days after the curtailment of their method. Treatment with the inhibitors OF MAO can be begun not earlier than 7 days after the curtailment of the method Celexa. One ought not to assign Celexa the pregnant and feeding with breast women, if potential clinical benefit does not predominate above the theoretical risk, since safety of preparation in the period of pregnancy and lactation in man is not established. Method of application and dose Celexa assign one time in a 24 hour period. Preparation can be used at any time of day independently of the consumption of food. Depressions: the therapy of depressions begins from the method 20 mg Citalopram in a 24 hour period. Depending on the individual reaction of patient and gravity of depression the dose can be increased to the maximum - 60 mg in a 24 hour period. Panicky disorder: during the first week of treatment is recommended the dose 10 mg Citalopram in a 24 hour period, then dose rises to 20 mg in a 24 hour period. Daily dose, depending on the individual reaction of patient, subsequently can be increased. Maximum dose - 60 mg/day. Obsessive-compulsory disorder: initial dose Celexa is 20 mg in a 24 hour period. The dose can be increased if necessary. Maximum dose - 60 mg in a 24 hour period. Elderly patients (older than 65 years). The recommended daily dose for the elderly is 20 mg. Depending on individual reaction and gravity of depression the dose can be increased to the maximum - 40 mg in a 24 hour period. With the hepatic insufficiency the method of preparation should be limited by the minimum recommended doses. Maximum dose - 30 mg in a 24 hour period. It does not be required with the small and moderately expressed kidney deficiency of the correction of doses. Side-line action Undesirable effects generic Celexa have transitory nature and are expressed weakly. They are observed during the first one-two weeks of treatment and usually substantially they weaken in proportion to an improvement in the state of patients. Are possible the appearance of dryness in the mouth, nauseas, sleepinesses, weaknesses, increased perspirations, tremor, agitation, insomnia, diarrhea, sexual disturbances. Celexa can be the reason for insignificant reduction in the frequency of the heart contractions, that usually it does not have clinical value. However, in patients with the originally low frequency of the heart contractions this can lead to bradycardia. In the exceptional cases during the application of large doses of preparation the development of convulsive fits is possible. Extremely rarely can appear hyponatremia, manifestations of serotonin syndrome, syndrome of cancellation, extrapyramidal disturbances, purple. With the inversion of phase and the development of maniacal state Celexa it must be abolished.
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